When I visited CyberpowerPC earlier this year they showed me a new system they were working on that used a really cool Mini ITX case. One of the unique features of the SFF case was that instead of the motherboard laying flat with the PSU above the cpu cooler it was hanging in a vertical position like most Mid and Full tower cases. This orientation allowed them to install a full 240 AIO watercooler, full length video card and still have plenty of airflow to keep the motherboard and video card cool.

The case they used was the Phanteks Enthoo EVOLV.