When Skylake came out we were tantalized with the possibilities for high-speed RAM exceeding existing top end kits. Kingston was nice enough to send over a Kingston HyperX Savage 3000MHz kit for us to check out, and with 16GB of dual-channel Savage timed at 15-16-16-39 and 1.35V, we should be looking at a screaming fast set of enthusiast RAM. The new dual-channel DDR4 is specially built for the Z170 Skylake chipset and we have heard rumors of compatibility with X99, but unless it's just an emergency, we highly recommend using dual-channel for Skylake and quad-channel for X99. The chipsets are set for, and expecting a specific type of RAM, and while we have run dual-channel in X99, we got slower speeds than using its native quad-channel. We tried some quad-channel in Z170, but had a lot of minor problems with that configuration. In short, while the pins and the layout is the same, and the RAM sockets are interchangeable, we recommend sticking with dual-channel in Z170 and quad-channel in X99.